Based on what I've seen, a team that can play very tough man to man defense against Kentucky has a chance of beating us. Conventional wisdom says that UK struggles more against a zone, but UK has been destroying zones lately with good shooting and good ball-handling.
An in-your face man to man might work because UK only really sees it in practice and we don't have a lot of guys adept at driving the lane to compensate for an over-extended defense. Man to man is really the only way to force UK into turnovers because UK does not tend to give up the ball on the press (another benefit of having tall guards) or against a zone.
Under normal circumstances, Florida's strategic defense that double teams the post and leaves all but 1-2 shooters open would be a decent strategy. Not this year--not with UK passing out of the blocks so well and making so many 3's.
This year, I think South Carolina, which plays almost exclusively man to man, will pose the biggest threat to UK. Their defense is solely dedicated to taking away threes and layups--which are a big part of UK's offense. Their weakness is that they allow mid-range jumpers all day and are not very good at anticipating several crisp passes in a row. As a result, UK will attack them and get several alley-oops against them, even if this means turning the ball over. Lyles will have the chance at a big day as well, as he has a phenomenal mid-range game.