Illinois at Indiana odds: Early point spread updated, How to Watch

No. 9 Illinois and No. 19 Indiana are set to clash in a monstrous Week 4 Big Ten matchup, with the game set to take place at Memorial Stadium in Bloomington, Ind. Both programs head into the game with undefeated 3-0 records.

Indiana has rolled Old Dominion (27-14), Kennesaw State (56-9) and Indiana State (73-0) to open its 2025 campaign, while Illinois owns wins over Western Illinois (52-3), Duke (45-19) and Western Michigan (38-0).

Ahead of ’s matchup, the early point spread and more have been revealed. All odds are courtesy of BetMGM. Despite being the lower ranked team entering the Week 4 matchup, the 19th-ranked Hoosiers opened as 4.5-point home favorites over the No. 9 Fighting Illini , with he over/under set at 52.5 points.

These programs last met in 2023, which marked the 73rd meeting between the two programs. Illinois held off Indiana 48-45 (OT) in a high-scoring affair thanks to a whopping 507 passing yards and four touchdowns from quarterback John Paddock. Illinois leads the all-time series 46-25-2.

How to watch No. 9 Illinois at No. 19 Indiana

Time: Saturday, 7:30 pm ET
Channel: NBC
Location: Memorial Stadim (Bloomington, Ind.)

It’s been a breezy start to the season for Indiana fresh off its appearance in the 2024 College Football Playoff. Much like Penn State, the Hoosiers have received criticism for opening the season against some less-than-stellar competition. It’s week four matchup against Illinois will mark its first against power-four competition this season.

The Hoosiers have won their three games by an average of 44 points per game, heavily impacted by that 73-0 walloping of Indiana State. Curt Cignetti‘s team is averaging 591.7 yards per game on offense (2nd most in Big Ten) and 52 points per game (4th in Big Ten), while holding opponents to just 220.7 yards per game (4th best in Big Ten) and 7.7 points per game (5th best in Big Ten).

Transfer quarterback Fernando Mendoza has been a more than worthy successor to Kurtis Rourke, as he boasts 708 passing yards, nine touchdowns and no interceptions through three games. The Hoosiers have gotten it done on the ground as well, as three different running backs boast at least 200 yards on the ground this season (Kaelon Black, Lee Beebe Jr. and Roman Hemby).

Although it made an appearance in the CFP last season, it did not win a game against a ranked team. With a win over No. 9 Illinois on Saturday, Indiana would notch its first ranked victory of the Curt Cignetti era and its first overall since Dec. 5, 2020 (No. 16 Wisconsin). It would be their first ranked win in Bloomington since Nov. 7, 2020 (No. 23 Michigan).

Meanwhile, Illinois just keeps on rolling. The Fighting Illini, fueled by quarterback Luke Altmyer‘s three total touchdowns, shutout Western Michigan 38-0. Through three games, the Altmyer led offense is averaging 412 yards and 45 points per game. The senior quarterback has completed 72% of his passes for 709 yards (236 per game) and eight touchdowns. He has yet to throw an interception.

Indiana‘s exciting offense will be meeting a stronghold in Illinois‘ defense, which has held two of its three opponents this season to three or less points. The matchup will certainly go a long way in potentially determining a spot in the Big Ten Championship or College Football Playoff.

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