I don't know enough about the other regions to give an educated guess, but after two weeks here are my rankings for Region C:
1. Sherando
2. Woodgrove
3. Heritage
4. Kettle Run
5. Loudoun County
6. Liberty
7. Dominion
8. Millbrook
Of those teams I'd give Sherando and Heritage the best chance to go undefeated, and if both did I imagine that Heritage would be the number 1 seed due to their beaten opponents being more likely to win games than Sherando's.
At least two of the teams listed in my top 8 will miss the playoffs due to only six teams making it in Region C. As it stands right now I think you could lose two games and still make it (3 might come down to tiebreakers), so if I had to pick two teams to miss the playoffs I'd probably go with Millbrook and Woodgrove.
- Millbrook because they're not the same team without Savon Smith. Loudoun County controlled the line of scrimmage and managed to shut their offense down for most of the game, so I have to believe that Kettle Run, Liberty, and Sherando will be able to do the same.
- Woodgrove because despite me believing they're the second best team in the region, they have by far the hardest schedule and there's not going to be any room for error if they drop games against 5A Broad Run and 5A Tuscarora. Following those two games they have to play Dominion, Heritage, and Loudoun County. I think a 7-3 Woodgrove could get in because their 5A opponents will win a lot of games to balance out the difference, but at 6-4 I'd guess they're watching from the sidelines.
All of that changes if the Dulles District teams cannibalize each other too badly though.
My surprise team is Handley. They're 2-0 on the year and I could see them winning six games or so. They have some good skill position players but I worry about their depth when it comes to facing the tougher teams on their schedule. I wouldn't overlook them though!
EDIT: Okay, here's my final 8:
A: (1) Lake Taylor vs. (2) Lafayette
B: (1) Dinwiddie vs. (3) Louisa
C: (1) Sherando vs. (2) Heritage
D: (1) G.W. Danville vs. (3) Salem