Syracuse at Notre Dame odds: Opening point spread released, How to Watch

Just two weeks remain in the 2025 regular season, and Notre Dame will have its Senior Day as Syracuse comes to town. Ahead of the matchup, the opening point spread has been released.

The Fighting Irish opened as 35.5-point favorites against the Orange, according to BetMGM. The over-under also opened at 51.5.

Notre Dame and Syracuse have not squared off since 2022 when the Irish got a resounding 41-24 victory at the Carrier Dome. This year, Marcus Freeman’s group will look to continue its winning ways as it looks to clinch a College Football Playoff bid.

How to watch Syracuse at Notre Dame

Time: Nov. 22nd, 3:30 p.m. ET
Channel: NBC
Location: Notre Dame Stadium, Notre Dame, Ind.

Early in the year, it looked the Week 13 game between Notre Dame and Syracuse would put Steve Angeli against his old team. However, the Fighting Irish transfer quarterback suffered a season-ending injury against Clemson, and the Orange have struggled to find success on offense since he went down.

Syracuse was on a bye in Week 12 as it got ready for its final two games of the year. The Orange are out of the bowl eligibility race, taking a 3-7 record into the matchup in South Bend.

For Notre Dame, the matchup marks another opportunity to further prove itself in the CFP race. The Fighting Irish have rattled off eight straight wins after dropping the first two games of the year, most recently picking up a victory at Pitt in Week 12 to improve to 8-2 on the year.

DISCLAIMER: This site is 100% for entertainment purposes only and does not involve real money betting.

The content provided in this article is intended for entertainment purposes only. All views and opinions expressed are the authors and reflect their individual perspectives on sports, betting, and related topics. This content should not be considered professional betting advice or the official views of On3. Please gamble responsibly. If you or someone you know is experiencing issues related to gambling, seek help from a licensed health professional. This blog is not liable for any losses, damages, or consequences resulting from betting activities.

Bets and betting odds data are powered by BetMGM. Gambling problem? Call 1-800-GAMBLER (available in the US), Call 1-800-327-5050 (MA), 1-800-NEXT-STEP (AZ), 1-800-522-4700 (KS), 1-800-BETS-OFF (IA), 1-800-270-7117 (MI), Call 877-8-HOPENY or text HOPENY (467369) (NY). Must be 21+. Visit BetMGM.com for terms and conditions. First Bet Offer for new customers only (if applicable). Subject to eligibility requirements.”