USC at Oregon odds: Opening point spread revealed, How to Watch

On Saturday, Oregon will host USC inside Autzen Stadium. The game will be Oregon and USC’s first meeting since joining the Big Ten.

Oregon defeated USC 36-27 when they last met in 2023. In fact, the Ducks have won their last three showdowns against the Trojans. Alas, USC still boasts a 38-23-2 all-time record over Oregon.

According to BetMGM, Oregon is a 9.5-point favorite in the pivotal matchup. Additionally, the over/under for the game is set at 59.5 points.

How to watch USC at Oregon

Time: Saturday, Nov. 22 | 3:30 p.m. EST, 12:30 p.m. PT
Channel: CBS
Location: Autzen Stadium (Eugene, OR)

It’s no surprise that oddsmakers are expecting a high-scoring affair. USC and Oregon each average over 35 points per game this season. Moreover, the two teams have proven they can put up massive numbers against quality competition.

The Trojans scored 31 points in a dominant win over Michigan earlier this year. Not to be outdone, Oregon racked up 34 points in a triumph over Northwestern in September.

The two teams’ quarterbacks are largely responsible for their success. USC’s Jayden Maiava is in his debut campaign as the Trojans’ full-time starter behind center. Likewise, Ducks QB Dante Moore is shining in the 2025 campaign after backing up Dillon Gabriel last season.

Of course, no team is complete without a strong defense to complement its offensive firepower. The Ducks boast a top-10 defense in the country this season. While USC can’t say the same, the program’s made major strides on defense since hiring defensive coordinator D’Anton Lynn last year.

Lynn and Co. will be hungry to make a statement on Saturday against Oregon. The Ducks won’t be lacking motivation, either. Another loss could knock Oregon out of College Football Playoff contention.

Fans won’t have to wait much longer to see the two West Coast powerhouses clash. Oregon and USC will face off on Saturday.

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