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LSU vs. South Carolina Odds: Books sees clear betting favorite

On3 imageby: Matthew Brune10/06/25MatthewBrune_
LSU's Harold Perkins

With LSU and South Carolina preparing to showdown in Tiger Stadium on Saturday night, more people have started shifting their attention to the SEC matchup and started betting on it.

The Tigers are 4-1 coming off of a road loss to Ole Miss, while the Gamecocks are 3-2 fresh off of a blowout win over Kentucky. Both teams are flawed, but it’s LSU who comes into this game as the massive favorites. The Tigers are currently favored by 10 on Bet MGM, a bump up from the 9.5 it was at the past week as Brian Kelly’s team is expected to take care of business.

The total for the game is at 44.5, a much lower number than any other LSU game, but for a team that has had its struggles on offense and has hit the under in every FBS game this year, the oddsmakers are skeptical either side finds many answers on offense.

We will have our Final Lines betting preview out on Friday, to breakdown every betting angle and make our pick of the week (which is 5-0), but until then, we wait to see how much more this line will move and get some answers about how the Tigers’ bye week really went.

Stay tuned to the Bengal Tiger for the latest news and intel.

LSU vs. South Carolina kickoff time set

LSU is set to play South Carolina at 6:45 p.m. CT on SEC Network, following the conclusion of Arkansas at Tennessee. Here are the official time slots and TV slates for this weekend’s SEC games.

DayDateGameNetworkTime (ET)
Sat10/11/2025Alabama at MissouriABC12:00 PM
Sat10/11/2025Washington State at Ole MissSEC Network12:45 PM
Sat10/11/2025Oklahoma vs. Texas (Dallas)ABC3:30 PM
Sat10/11/2025Arkansas at TennesseeSEC Network4:15 PM
Sat10/11/2025Florida at Texas A&MESPN7:00 PM
Sat10/11/2025Georgia at AuburnABC7:30 PM
Sat10/11/2025South Carolina at LSUSEC Network7:45 PM

On3’s Pete Nakos tabs LSU vs. South Carolina as a Top 10 game to watch in Week 7

“LSU and Brian Kelly are coming off the bye after losing at Ole Miss. Garrett Nussmeier’s health remains a concern as he deals with an abdominal injury. How he looks coming off a week of rest will be key to what the remainder of the season looks like for the Tigers. South Carolina already has two losses but could re-enter the CFP mix with a win in Death Valley at night.” – Nakos

It’s another significant challenge for the Tigers who look to get quarterback Garrett Nussmeier back on track along with the overall offensive production.

On3’s Brett McMurphy has the Tigers ranked as the No. 7 team in the country on his AP ballot and is high on the defensive effort. Still, it’s the offense that has him and others operating with caution when discussing this team.

“The Tigers, who were off this week, host South Carolina on Saturday. LSU’s offense continues to struggle. The Tigers have not scored more than 20 points against their three Power 4 opponents this season and have the SEC’s fifth-worst offense.”