Notre Dame football score predictions: Irish vs. Purdue national picks

No. 24 Notre Dame hosts Purdue at 3:30 p.m. ET on Saturday in South Bend, when the Irish will look to pick up their first win of the 2025 season. The national experts largely think they’ll do that, by various margins.

Here are the national picks for Notre Dame vs. Purdue.

Bleacher Report: Notre Dame 38, Purdue 14

“Clinging near the edge of the Top 25, Notre Dame should finally put a notch in the win column this weekend. Purdue is a major work in progress offensively.” — David Kenyon

Source: 2025 Week 4 College Football Predictions for Every Game

USA TODAY Sports: All six pick Fighting Irish

Matt Hayes: Fighting Irish
Jordan Mendoza: Fighting Irish
Paul Meyerberg: Fighting Irish
Erick Smith: Fighting Irish
Eddie Timanus: Fighting Irish
Blake Toppmeyer: Fighting Irish

Source: College football Week 4 picks, predictions: SEC, Big Ten clashes lead schedule

ESPN analytics: Notre Dame by 20.4 (SP+); Notre Dame by 20.3 (FPI)

“Well, Notre Dame, it’s time to start scoring some style points. After losses to Miami and Texas A&M, the Irish will have to win out to have serious hope of a CFP shot, and they might have only one more genuine marquee win opportunity — USC in Week 8, and that’s only if the Trojans maintain their current form. So, it’s time to wreck some opponents. (Purdue might have something to say about that. Especially if the Irish defense doesn’t start defending.) — Bill Connelly

Source: College football Week 4: DJ Lagway, Arch Manning look to get right

New York Post: Notre Dame -24.5

“The Irish must run the table to have a chance of returning to the playoff. The victim of last season’s 66-7 beatdown is a good place to start.” — Howie Kussoy

Source: College football Week 4 predictions: Picks against the spread

Athlon Sports: All three pick Fighting Irish

Steven Lassan: Fighting Irish
Thomas Neumann: Fighting Irish
Kyle Wood: Fighting Irish

Source: College Football Picks: Expert Predictions for Every Game in Week 4

College Football News: Notre Dame -25.5

“All of a sudden, the Notre Dame defense will start to look okay against an opposing offensive line that’s not loaded with future NFL starters. Marcus Freeman and the Irish will try to erase that 0-2 start on the first drive. It might take a full four quarters to get there, and a lot of breath-holding as Purdue drives late, but the Irish D will look to make a statement.” — Pete Fiutak

Source: 10 Best College Football Picks Against the Spread Week 4: Notre Dame vs Purdue, Michigan State vs USC, Rivalry Games