| August 30 | 5:45 p.m. | at Louisiana Tech* | Joe Aillet Stadium • Ruston, LA | ESPN2 | L 14-22 | 25,224 |
| September 6 | 6:00 p.m. | Southeastern Louisiana* | Davis Wade Stadium at Scott Field • Starkville, MS | W 34-10 | 41,938 | |
| September 13 | 6:00 p.m. | #9 Auburn | Davis Wade Stadium at Scott Field • Starkville, MS | ESPN2 | L 2-3 (Missed at least one field goal) | 55,082 |
| September 20 | 12:10 p.m. | at #15 Georgia Tech* | Bobby Dodd Stadium • Atlanta, GA | L 7-38 (Shouldn't have scheduled this game) | 48,402 | |
| September 27 | 6:35 p.m. | at #5 LSU | Tiger Stadium • Baton Rouge, LA | ESPN2 | L 24-34 | 92,710 |
| October 11 | 1:30 p.m. | #13 Vanderbilt | Davis Wade Stadium at Scott Field • Starkville, MS | W 17-14 | 43,619 | |
| October 18 | 6:00 p.m. | at Tennessee | Neyland Stadium • Knoxville, TN | L 3-34 | 98,239 | |
| October 25 | 6:00 p.m. | Middle Tennessee*
| Davis Wade Stadium at Scott Field • Starkville, MS | W 31-22 | 40,024 | |
| November 1 | 1:30 p.m. | Kentucky | Davis Wade Stadium at Scott Field • Starkville, MS | L 13-14 (Missed FG and extra point) | 40,168 | |
| November 15 | 6:45 p.m. | at #1 Alabama | Bryant-Denny Stadium • Tuscaloosa, AL (Alabama–Mississippi State rivalry) | ESPN | L 7-32 | 92,138 |
| November 22 | 1:30 p.m. | Arkansas | Davis Wade Stadium at Scott Field • Starkville, MS | W 31-28 | 42,056 | |
| November 28 | 11:30 a.m. | at #25 Mississippi | Vaught-Hemingway Stadium • Oxford, MS (Egg Bowl) | Raycom | L 0-45 | 55,231 |