Antibodies Immunity

[engie]

https://www.medrxiv.org/content/10.1101/2020.07.21.20159178v1

The gist of it is that symptomatic Covid patients among the earliest confirmed worldwide are still showing extensive antibodies for COVID, basically meaning there’s at least medium-term immunity to it. They are at like 70% after 6 months.

Which I feel like was the basic common sense of this thing all along(That the term of immunity would fall beyond the common cold but short of sars/MERS of which there’s never been confirmed reinfections) but it’s nice to start seeing it confirmed.

 

[paindonthurt_]

Very good news.

Does this mean I’ll never die now?

 

[thatsbaseball]

The more I read about this it's becoming clearer that "symptomatic" is a very key word here.

 

[Car Ramrod.sixpack]

Since my recovery I tested positive for antibodies and have been donating plasma every 2 weeks. I will have to get another antibody test in October (6 after my first test). I wonder if I continue to be exposed to the virus will my body continue to produce the antibodies indefinitely? I had a fairly rough time with the virus and knowing my luck I would catch it again, so I really don't want to risk it.

 

[Crazy Cotton]

That's great you are donating plasma.

 

[57stratdawg]

Thanks for your help in this.

 

[Raiderdawg.sixpack]

Since my recovery I tested positive for antibodies and have been donating plasma every 2 weeks. I will have to get another antibody test in October (6 after my first test). I wonder if I continue to be exposed to the virus will my body continue to produce the antibodies indefinitely? I had a fairly rough time with the virus and knowing my luck I would catch it again, so I really don't want to risk it.

If you are exposed again & assuming normal immune function, your immune system should have memory B and T cells that recognize the virus. You would have a faster and more robust immune response to subsequent exposures, which should lessen the illness. More exposures under normal cases should lead to an immense system that has an extremely high antibody titer and a high number of memory cells ready to respond.


The amount of circulating memory cells drops over time. B cells produce antibodies, so every timing you get an antibody titer, you are essentially assaying for the presence of memory cells that are specific to the virus.

The caveat here is if this virus causes immune dysfunction in a second exposure, basically the response is so robust you have systemic inflammation and can go into shock. That should not be the case, but that’s a fear with a unknown virus. The second fear is that your body doesn’t generate enough memory the first exposure, so your memory cells deplete before your second exposure, so your immune response is like you never had it the first time. This would be bad for people that had physical damage from the first infection. That’s the fear from reports of people getting sick and not having antibodies after.


All that said, from this study, hopefully most people that are infected or eventually get the vaccine have a normal strong immune response that generates enough memory to provide protection against another exposure.

 

[Car Ramrod.sixpack]

Thanks for your help in this.

It's the least I can do to help someone in need. I try to mention to anyone that has recovered that every donation can help 4 people.

 

[johnson86-1]

If you are exposed again & assuming normal immune function, your immune system should have memory B and T cells that recognize the virus. You would have a faster and more robust immune response to subsequent exposures, which should lessen the illness. More exposures under normal cases should lead to an immense system that has an extremely high antibody titer and a high number of memory cells ready to respond.


The amount of circulating memory cells drops over time. B cells produce antibodies, so every timing you get an antibody titer, you are essentially assaying for the presence of memory cells that are specific to the virus.

The caveat here is if this virus causes immune dysfunction in a second exposure, basically the response is so robust you have systemic inflammation and can go into shock. That should not be the case, but that’s a fear with a unknown virus. The second fear is that your body doesn’t generate enough memory the first exposure, so your memory cells deplete before your second exposure, so your immune response is like you never had it the first time. This would be bad for people that had physical damage from the first infection. That’s the fear from reports of people getting sick and not having antibodies after.


All that said, from this study, hopefully most people that are infected or eventually get the vaccine have a normal strong immune response that generates enough memory to provide protection against another exposure.

Doesn't sound as scientific as the info I get on facebook, but thanks, I guess.**

 

[L4Dawg]

https://www.medrxiv.org/content/10.1101/2020.07.21.20159178v1

The gist of it is that symptomatic Covid patients among the earliest confirmed worldwide are still showing extensive antibodies for COVID, basically meaning there’s at least medium-term immunity to it. They are at like 70% after 6 months.

Which I feel like was the basic common sense of this thing all along(That the term of immunity would fall beyond the common cold but short of sars/MERS of which there’s never been confirmed reinfections) but it’s nice to start seeing it confirmed.

I've been out of pocket today and I was coming to post on this one. That's the best news I've seen in a while. That bodes well for a vaccine too. Keep in mind that that is a Chinese study, and it's a pre-print, but if confirmed that is very good news. Also this was the best Thursday for Mississippi numbers in a while. Masks work.