Never underestimate how bad the Lions can be. Brees, P. Thomas, Moore, and Colston will all have big days and the Lions will do what the Lions do: lose. It will probably be close but Brees won't let it happen (I hope).
The Saints will score at will on the Lions defense. The Lions would have a hard time stopping some college teams. They have zero pass rush. Brees will sit back there and pick them apart.