yeah I think so; old cliche of it's all about the match-up. 6s look to be top 25 quality. 7s just outside the top 25.
assuming it goes how it's designed to (seldom does), the 3-6 game should be much tougher than the 2-7 game. could also argue it may be better to have the top 3 seed than sneaking in as the last 2 seed. getting into the nitty gritty details, but I think it's supposed to be the "last" 2 seed is pitted in the region with the No. 1 overall seed. inversely, the last 1 seed is supposed to draw the best 2 seed.
I'm not sure that they follow the formula all the time though. in 2010, WV was probable for a 1 seed and I think got the top 2 seed, but was placed in the region with KY, the "second" 1 seed behind No. 1 overall Kansas. say that 10 times fast.
my take has been avoid the top half of any region because there lurks a 1. not invincible, but they are 1 for a reason. top half is filled with potential landmines. 8/9 game is equal and has guaranteed meeting with the 1 in the first weekend of every NCAA tournament in history. 5/12 game often is trouble & the 1 awaits in the Sweet 16 like last year. our season devastatingly ended there after a clinic we put on vs MD.
I'm perfectly fine with the best 3 line if it happens. UConn was a 3 in 2011 and won the national championship. Was there in Anaheim to see them win the West Regional. UConn won it all again in 2014 starting on the bottom half again as the 7.