Here's something I've been doing for a few years it definitely helps in the computer generated drafts-
You will field a better team if you move a couple of highly ranked TE, K, Def/SP into your top 35-45. Also, if your league plays two QBs you definetly want to move a significant amount (around 8) into your top 45, and also trickle in a few more receivers. The reason this makes you team better is that most of the top 100 are running backs (50+) and this probably plays out to be true at season's end. But while other folks are getting their 3rd and 4th running back you will be getting the top players at other positions that you will actually be able to play. I also believe there is more risk with the runningback position.
You will field a better team if you move a couple of highly ranked TE, K, Def/SP into your top 35-45. Also, if your league plays two QBs you definetly want to move a significant amount (around 8) into your top 45, and also trickle in a few more receivers. The reason this makes you team better is that most of the top 100 are running backs (50+) and this probably plays out to be true at season's end. But while other folks are getting their 3rd and 4th running back you will be getting the top players at other positions that you will actually be able to play. I also believe there is more risk with the runningback position.