You basically have two options. 1) Draw Varnado out of the lane with your offense to open up the middle, or 2) don't go in there.
He alone is the main reason why I said you were probably Memphis's biggest threat in their entire bracket in last year's NCAA tourney. And you probably gave them their toughest game primarily because of him. He can basically shut down a dribble drive offense like Memphis's, because he gives your team the freedom to not have to collapse or double when a guard gets a step into the lane. I'll be really curious to see what happens when you play South Carolina. I'll be curious to see if Downey can still get his game going in the lane. For a guy that's under 6 feet tall, I've been really impressed with his ability to avoid blocked shots and still score.