Keeping it simple. Trains in Chicago are by color. I would take the Blue Line.
Trains
Blue Line
The stadium is just a few blocks north of the
Blue Line. The shortest walk is by exiting the station to Damen Avenue (western-most exit) and walk north on Damen to Madison.
To get to the Illinois Medical District stop from the west (including the far West Side and the communities of Forest Park and Oak Park), take a Blue Line train toward O'Hare. From the east and north (including downtown, the Northwest Side, northwest suburbs east of O'Hare and directly from O'Hare Airport), take a Blue Line train toward Forest Park.
Green and Pink Lines
The stadium is two blocks south and three blocks west of the
Pink Lines.
To get to the Ashland/Lake station from the west, take a Green Line train toward Ashland/63rd or Cottage Grove, or a Pink Line train toward the Loop. From the east (including downtown or the South Side portions of the Green Line), take a Green Line train toward Harlem/Lake or a Pink Line train toward 54th/Cermak.