You can get the same mismatches in the WCO, the run and shoot, and even the wishbone. I remember the 49ers had it where a LB was covering Jerry Rice one time when they beat the Cowboys.
What are we really talking about? I may be over generalizing, but as I understand it, there are two extremes to the spread: 1) The spread option rushing attack, most often associated with West Virginia/Rodriguez, and 2) The spread that's run by Kentucky and Texas Tech, where you line up with 5 wides, throw short passes alot, and use no huddle alot. Nobody seems to argue that running the spread option exposes your quarterback to injury, and it's fairly gimmicky. Teams will figure out how to stop that, and West Virginia has had success doing it primarily because a) very few other teams were doing it, and b) they have two Heisman trophy candidates in their backfield, with unbelievable speed.
As far as the pass heavy spread, that is what lengthens the game and exposes your team to turnovers. When Coach says that what an offense does has no effect on the defense and other aspects of the game, he proves his idiocy. That type of attack is great if it works: if your team never throws a pick or drops a pass, but it's also extremely risky because you are putting the ball up for grabs, AND you are lengthening the game because you are going to inevitably have some incomplete passes.
In short, with the history of our personnel that we have had at Mize St., I don't want our quarterbacks running the option all day (because we typically don't have the speed and/or depth to do that), and I don't want our quarterbacks putting the ball up in the air (because we typically hurt ourselves with turnovers). If you want to put 5 wides out there and run Dixon, that's fine, but as Todd said, you can do that in the WCO, Spread, Run and Shoot, whatever. You don't have to change schemes to do that. At the end of the day, no matter what offense you run, if you can't make teams respect your passing attack, you are going to have safeties selling out and cornerbacks crashing in until you burn them: 5 wide or a stacked I. So when we can't throw the ball, and we are going to have to run it, I'd just as soon have an extra tight end or fullback in the game instead of hoping Co-Eric Riley can block his man, because the defense is coming anyway.
Coach, you act like the spread is the magic bullet. It's not. We have coaches that have shown very little offensive creativity, and we have an offense that has shown very little in the way of execution. If that's going to be the case, give me a conservative offense that doesn't get you beat all day.