I just came from up there because we were in Pittsburgh for a conference a few weeks ago. Driving through Cincy was not a problem but we did miss the rush hours both on the way up and down. In Columbus, there is a bit of construction going on the 70/71 leg and interchanges near downtown, so it may be worth taking 270 to avoid that, especially if it is near rush hour. I think most of the construction is on the South 71/West 70 side, too.