I've been both and the Springfield route isn't bad. Just don't plan on eating anywhere between Jonesboro and Springfield, but it's not bad.
The interstate felt much longer to me. 250ish miles from St. Louis to KC is pretty rough, and there isn't much more than a few pilots between Columbia and KC.
I prefer the Springfield route, personally, but when I drove these routes, I flew solo and I don't stop much. Throw my opinion out the window if you have kids.