OT: These weight loss drugs

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She Mate Me

Heisman
Dec 7, 2008
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I havent thought of Kelly Osbourne in over 20 years since their show was first on, but still...I wouldnt have guessed this is her if I were given 15 guesses.
If she is healthier and happier, cool. Totally unrecognizable. I dont think a sketch artist would draw the picture on the right if asked to add 25 years to the picture on the left.


Her cosmetic and hair choices certainly do nothing to improve the situation.
 

Dawg1976

All-Conference
Aug 22, 2012
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Here is an idea, quit eating so much and exercise.
I’m only 10lbs overweight according to the charts. My doctor asked me how I was doing the other day and I said fine but knew I needed to lose a few lbs. He replied that I’m not fat and don’t worry about it. I love my Dr…ha. I have been exercising a good bit so I’ve toned up making me look healthy. I’m 71 and feel like 40. At this point if I’m offered a dessert I’m not passing it up. Plus if I did lose 10+ lbs it’s just going to make me look older. That’s my story and I’m sticking to it. 😉
 

She Mate Me

Heisman
Dec 7, 2008
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I will say this. I'm someone who has lost a good bit of weight at a pretty slow and reasonable pace in my 50's after being "somewhat" to "way too" fat nearly all my adult life.

The thing is, when you're fat that long, the skin just doesn't snap back to attention quickly, if at all. And no, I'm not remotely vain enough to pay somebody to snap it back. It's enough to get the praise from my relieved joints on a daily basis.

Oh and when you're not carrying around an extra 40 or 50 lbs of blubber, unsurprisingly you lose some muscle mass in your legs. But they feel stronger when going up or down steps. Weird***
 
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tldawg85

Redshirt
Mar 28, 2008
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These medicines are wonder-drugs when used appropriately, though they are not silver bullets. My dad died at age 53 from a massive heart attack...had high BP, diabetes, overweight, etc.

At age 38 I was quickly headed in that direction and I saw my death sentence 15-20 years away -- pre-diabetic, 40-50 pounds overweight, no muscle mass to speak of, high BP ,with 2 kids under 10 years old.

I took a chance on compounded Tirzepatide with a telehealth company and my life changed. I lost 50 pounds in 4 months down to the appropriate weight for my 5'8 frame. Bloodwork improved to levels I've never had even in my 20s...stopped taking my BP med, lowered Triglycerides to less than 50% of what they were, raised HDL, lowered LDL, etc. **It was because I started exercising literally every day** I totally agree that you can't just take the drug and expect miracles...but if you put in the work alongside the drug, (seeming) miracles are possible.

After getting down to my ideal weight, I started lifting weights 5 days a week and have a fairly impressive physique. At age 40 I am in by far the best shape of my life and I am looking forward to 30+ more years in healthspan. These GLP1s are a tool. Use them wisely.
 

DerHntr

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Sep 18, 2007
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It would be nice if they’d make many other peptides legal to sell. I’d buy BPC157 stacked with TB500 today if I could get it from a reputable company or from a local compounder. It’s illegal for sale in the US. So, I don’t know exactly what the places selling it online or in stores have in the bottle. I even saw a bottle of it in a local pharmacy recently, but still can’t get around the label saying “not for human use.”
 

tldawg85

Redshirt
Mar 28, 2008
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It would be nice if they’d make many other peptides legal to sell. I’d buy BPC157 stacked with TB500 today if I could get it from a reputable company or from a local compounder. It’s illegal for sale in the US. So, I don’t know exactly what the places selling it online or in stores have in the bottle. I even saw a bottle of it in a local pharmacy recently, but still can’t get around the label saying “not for human use.”
I was hoping there would be some progress on this front, as RFK Jr. is apparently a big fan of peptides in general (though not necessarily GLP1s), so I'd hoped there would be approvals for the more-commonly-accepted ones like TB4/500 and BPC157. Of all the things I cringe about with him, this was a bright spot - but nothing I'm aware of yet.
 

OG Goat Holder

Heisman
Sep 30, 2022
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That is the most asinine statement I have ever seen you make. One example from my personal life: if my wife stops taking insulin she is dead in a couple of days. Sometimes the only way to remain healthy is to take certain drugs for LIFE.
It’s always about you, isn’t it?

Insulin, like test, is a biological medication rather than a chemical drug. I alluded to that in my OP (that you quoted but cut).

Get over yourself.
 
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bkmaroon

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Sep 26, 2023
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My dr put me on it for my beetus. Made me nauseous at all times. If my eyes were open, i wanted to vomit. Got off after 2 weeks.
Family members have had the same results.

At some point and time there has to be a safer alternative, right?
 

birdawg

Sophomore
Aug 13, 2009
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Not only are they unattractive, the fact they can't discipline themselves makes them even more disgusting. Burn more calories than you eat. That's it.
 
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L4Dawg

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Oct 27, 2016
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It’s always about you, isn’t it?

Insulin, like test, is a biological medication rather than a chemical drug. I alluded to that in my OP (that you quoted but cut).

Get over yourself.

OH good grief, you really are ignorant. Most insulin is synthetic now. It’s no different than any other drug.

Ok, how about one that fits your laughter inducing criteria…..lisinopril. Healthier to take it or walk around with uncontrolled hypertension? You were just flat out WRONG with your statement. Heck even the drugs in the OP are necessary to maintain health for some people.
 

L4Dawg

All-American
Oct 27, 2016
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Drugs enrich life, if done correctly and in moderation. Not all of them are meant to be used in perpetuity or habitually.
You are wrong there, completely wrong. Shall we talk about cardiac drugs of most classes? Shall we talk about antihypertensives? Shall we talk about anti hyperglycemics? Shall we talk about immunosuppressants for those with auto immune diseases or organ transplants? I could go on and on and on. You flat out don’t know what you are talking about.

Also do you know what the drugs in the OP are actually for?
 
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jxndawg

Freshman
Dec 26, 2009
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Not a doctor, but work with a lot of them. They all say that, barring any major, unknown, negative side effects, this class of drugs will be revolutionary. Obesity causes a cascade of other health problems, and anything that's silver bullet-adjacent for obesity could mitigate tons of other chronic conditions, from hypertension to diabetes. Of course they also recommend exercise and healthier diets, but just bringing an obese person's weight down really moves the needle.
 

floristgump22

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Aug 5, 2025
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I have lost 50 lbs on zepbound. Started on ozempic but had side effects. It definitely works but there have been periods over the last 3 years where I got lazy and or forgot to refill it and I went a month or 2 without it. That appetite comes roaring back. I gained 15 lbs the last “break” I took. Unless you are disciplined and eat right/exercise you will gain it all back quickly.
 
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ronpolk

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May 6, 2009
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Not a doctor, but work with a lot of them. They all say that, barring any major, unknown, negative side effects, this class of drugs will be revolutionary. Obesity causes a cascade of other health problems, and anything that's silver bullet-adjacent for obesity could mitigate tons of other chronic conditions, from hypertension to diabetes. Of course they also recommend exercise and healthier diets, but just bringing an obese person's weight down really moves the needle.
I can’t understand why some care if people are using GLPs to loose weight. I work with a handful of people who are in their 40’s and can’t take the stairs up 1 floor because they are so obese. These people aren’t about to become gym rats but at least wouldnt be obese if they took these drugs.
 
Nov 16, 2005
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I can’t understand why some care if people are using GLPs to loose weight. I work with a handful of people who are in their 40’s and can’t take the stairs up 1 floor because they are so obese. These people aren’t about to become gym rats but at least wouldnt be obese if they took these drugs.
People that shame others for taking meds to lose weight are being ignorant honestly.

Just because losing weight for someone else is easy doesn’t mean it is for others. The best description I’ve seen for GLP1 meds is it cuts out the food noise which is an addiction for many that they can’t cut out.
 

L4Dawg

All-American
Oct 27, 2016
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You cannot factually prove my statement incorrect.
I can, and have. You are the worst kind of ignorant fool on this. You need to quit AFTER you have lost. That you wont proves exactly what you are: I pity you actually. God help you.
 
Feb 9, 2019
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I’m a doctor that has been prescribing GLP1s since victoza first came out. If tolerated and adequately covered by insurance, they’re awesome for diabetes, weight, cardiovascular protection, renal protection, liver disease, sleep apnea; and likely substance use disorders. But I’ve had several rather obese patients who simply didn’t lose much weight on them ( they did not make corresponding lifestyle changes); and a few that cut back on them to excessive weight loss and muscle mass loss. And there will continue to be potential for GI issues with them; antecdotally, this is worse with poorly controlled diabetics.

But I’ll add this. I’m in my 40s, perfect BMI, eat reasonable, and exercise consistently. And it’s tempting to criticize people who are obese. But approx 25% of folks have a genetic/metabolic make up in which their body holds onto fat more aggressively. And for those folks, it truly is NOT just a matter of “calories in, calories out”. That’s a protective trait if you live in sub Saharan Africa. But they’re generally screwed in the US. So I would strongly discourage generalized fat shaming (except for Renardo Sibley; he was a fat turd).
 

PK Dawg

Junior
Jul 17, 2022
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Where can people get these drugs? What is the cost without insurance? What about these peptides are any of those safe?
A lot of grey market suppliers for “research use only” is their loop hole. I’ve sourced from purapeptides.com and eliteresearch for years now with no issues. My peptide dr friend tells me as long as they are getting 3rd party certified/tested you are good to go.
There are a whole lot more peptides out there tha just the fat loss ones
 

PK Dawg

Junior
Jul 17, 2022
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My dr put me on it for my beetus. Made me nauseous at all times. If my eyes were open, i wanted to vomit. Got off after 2 weeks.
I had a similar reaction to semaglutide, but no nausea with tirzepatide, and a mild with Reta.
I’ve heard similar results from many
 

PK Dawg

Junior
Jul 17, 2022
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It would be nice if they’d make many other peptides legal to sell. I’d buy BPC157 stacked with TB500 today if I could get it from a reputable company or from a local compounder. It’s illegal for sale in the US. So, I don’t know exactly what the places selling it online or in stores have in the bottle. I even saw a bottle of it in a local pharmacy recently, but still can’t get around the label saying “not for human use.”
After the first prick you never notice that label again. My peptide dr friend tells me as long as they are 3rd party tested they’re as safe as any compound pharmacy. It’s all sourced from the same few places.
try eliteresearchusa.com
 
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paindonthurt

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Apr 7, 2025
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You lil guys can gain an advantage too


A man who took Mounjaro to lose weight has claimed that it came with the added benefit of adding three inches to his manhood.
I think the inches were there but they were hidden by a fuda

ETA: I realized fat FUDA was redundant.
 
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paindonthurt

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I havent thought of Kelly Osbourne in over 20 years since their show was first on, but still...I wouldnt have guessed this is her if I were given 15 guesses.
If she is healthier and happier, cool. Totally unrecognizable. I dont think a sketch artist would draw the picture on the right if asked to add 25 years to the picture on the left.

She needs to lose some hair
 
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