That's basically the premise behind the WCO. It's there to help less talented personnel even the playing field against more talented teams. Essentially, everything is done off pre-snap reads, and if someone misreads the defense it doesn't work. It works well with pro ball because you get so much practice time and your whole day can be devoted to film study, etc. Also, you can get and keep players for an extended number of years. In college, it's more difficult because you only get players for 4 years, and you have limited practice time.
It can work at the college level, but you have to have smart players, and you have to run a somewhat simpler form of the offense.
I compare it a little bit to the 4-2-5 defense. The system itself is not a bad system, but it didn't work at all at Ole Miss because it required the defensive players to make a lot of pre-snap adjustments for it to be successful. And given the level of intelligence of athletes in the state of Mississippi and the lack of football smarts in the state of Mississippi, the 4-2-5 never had a chance at Ole Miss. It worked fine at a school like Western Michigan though, just as the WCO can work fine at a school like Stanford. However, I have a hard time believing the WCO will work consistently at a school like MSU.
