I've been taking the 78, 45, & 82 (or Old W Point Rd) route forever.
Wouldn't consider anything else. Now, on game day for an 11 AM game, traffic can get bogged down in West Point. So, to be conservative, plan on an extra 20-30 minutes to get through there, unless you know a way to get off of 45 & by-pass the heart of W Point.
Also, as far as getting on 78 in Memphis, DO NOT get on 78/Lamar off of I-240. Take 240 around to 385/Bill Morris Parkway and take either Hacks Cross or Byhalia Road to 78. The traffic lights on Lamar, especially if there's a lot of truck traffic, will make you want to slam your head into the windshield.