IMHO, I doubt Pitino resigns at the end of the season, simply because I don't think that he wants to look like he's bolting after leaving U of L's basketball program in shambles. He's already not very well-liked by a majority in Kentucky; I doubt his ego would allow him to tarnish his reputation in Jefferson County as well. I think that he'll stick around long enough to at the very least get the Cards back up on their toes.
But anyway, speaking of coaches that aren't very well-liked in Kentucky -- I just realized that Louisville's 2-0 record versus Coach Gillispie might be vacated! I bet he'll like that. XD