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Running Back

Editor’s note: Our off-season position preview series will highlight each position room and provide an early look into Louisville football in 2026.

Louisville running back Isaac Brown will return for the 2026 season, On3 has learned. 

isaac brown (1)

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Cardinal Sports

Offseason position preview: Running back

With the 2025 Louisville football season officially behind us, it’s time to grade each position group.   The Cardinals ultimately finished the

Dec 23, 2025; Boca Raton, FL, USA; Louisville Cardinals quarterback Miller Moss (7) and wide receiver Antonio Meeks (15) celebrate a touchdown pass against the Toledo Rockets during the third quarter of the Boca Raton Bowl at Flagler CU Stadium. Mandatory Credit: Jeff Romance-Imagn Images

Louisville football 2025 position grades: Offense

The college football transfer portal doesn’t open until January 2, but Louisville has already seen movement following the conclusion of the season,

Louisville Cardinals running back Isaac Brown (1) celebrates with fans in the end zone after a big fourth quarter touchdown run against James Madison during the Cards' second college football game Friday September 5, 2025 at L&N Credit Union Stadium in Louisville, Kentucky.ouisville Cardinals running back Isaac Brown (1) celebrates with fans in the end zone after a big fourth quarter touchdown run against James Madison during the Cards' second college football game Friday September 5, 2025 at L&N Credit Union Stadium in Louisville, Kentucky. © Matt Stone/Courier Journal / USA TODAY NETWORK via Imagn Images

Louisville Cardinals running back Isaac Brown (1) celebrates with fans in the end zone after a big fourth quarter touchdown run against James Madison during the Cards' second college football game Friday September 5, 2025 at L&N Credit Union Stadium in Louisville, Kentucky.© Matt Stone/Courier Journal / USA TODAY NETWORK via Imagn Images

What are Louisville's priorities entering the transfer portal?

Typically, something that starts with “in memorium” or “obituary” is preceded by a death. Well, the Louisville football program is still very much

Dec 23, 2025; Boca Raton, FL, USA; Louisville Cardinals head coach Jeff Brohm raises the trophy after defeating the Toledo Rockets in the Boca Raton Bowl at Flagler CU Stadium. Mandatory Credit: Jeff Romance-Imagn Images

Obituary: The 2025 Louisville football season

BOCA RATON, Fla. —  The University of Louisville football team relied on its defense all season long. And it was that side of the football that

Dec 23, 2025; Boca Raton, FL, USA; Louisville Cardinals players celebrate after defeating the Toledo Rockets in the Boca Raton Bowl at Flagler CU Stadium. Mandatory Credit: Jeff Romance-Imagn Images

How it happened: Louisville beats Toledo in Bush's Boca Raton Bowl of Beans

Louisville looks to enter 2026 with a Boca Raton Bowl win over Toledo. The Cardinals and Rockets both finished the regular season with an 8-4 record

Louisville Cardinals running back Braxton Jennings (46) runs for a gain against Kentucky as the Louisville Cardinals football team dominated the Wildcats 41-0 Saturday, November 29, 2025 in Louisville, Kentucky at L&N Federal Credit Union Stadium.

Keys: Louisville takes on Toledo in the Boca Raton Bowl

Who says bowl games are meaningless?   Louisville and Toledo are set to kick off in the Bush’s Beans Boca Raton Bowl next Tuesday, and from an

Oct 25, 2025; Pullman, Washington, USA; Toledo Rockets defensive tackle Martez Poynter (8) reacts after being called for a penalty during a game against the Washington State Cougars in the second half at Gesa Field at Martin Stadium. Washington State Cougars won 28-7. Mandatory Credit: James Snook-Imagn Images

At a glance: Louisville to face Toledo, one of nation's best defenses, in Boca Raton Bowl

Kentucky (5-6, 2-6) is stepping out of conference play to end the 2025 regular season. The Wildcats will be looking to sweep the non-conference on

Louisville’s coach Jeff Brohm brings his team out onto the field against Virginia at L&N Stadium Saturday. Oct. 4, 2025. © Scott Utterback/Courier Journal / USA TODAY NETWORK via Imagn Images

KSR+ Football

KSR+

Scouting Report: Louisville Cardinals

Depleted with injuries, Jeff Brohm’s Louisville Cardinals enter the 37th edition of the Governors Cup coming off three straight losses.   On the

Seth McGowan, Cutter Boley, and Kentucky visit Louisville

Sep 13, 2025; Lexington, Kentucky, USA; Kentucky Wildcats quarterback Cutter Boley (8) hands the ball off to running back Seth McGowan (3) during the first quarter against the Eastern Michigan Eagles at Kroger Field. Mandatory Credit: Jordan Prather-Imagn Images

At a glance: Injured Louisville hosts motivated Kentucky for Governors Cup

Louisville may need to host open tryouts to field a football team against Kentucky. Okay, that is a bit over the top, but it isn't too far from the

Louisville Cardinals' senior wide receiver Chris Bell (0) during a recent practice on August 4, 2025 before the start of the 2025 football season. In 2024, Bell had 43 receptions for 737 yards with four touchdowns. He averaged 17.1 yards per catch.

KSR Football

Injuries Add Up for Louisville and Kentucky Ahead of Governor's Cup

Editor’s Note: This article includes the latest college football injury intel from On3’s Chris Low, Brett McMurphy and Pete Nakos. This story

week 13 college football injury updates

On3 Football

College Football Injury Report: Latest Week 13 updates at Ohio State, Arizona State, LSU & more

Once more, Louisville football will be down several starters as the Cardinals head to SMU (7-3, 5-1) in the final road game of the season.   Notably,

Nov 1, 2025; Blacksburg, Virginia, USA; Louisville Cardinals running back Keyjuan Brown (22) runs the ball for a touchdown against the Virginia Tech Hokies during the fourth quarter at Lane Stadium. Mandatory Credit: Brian Bishop-Imagn Images

Player availability report: Louisville, SMU

Louisville's costly mistakes led to a 20-19 loss to Clemson. The Cards drop to 7-3 after an embarrassing amount of penalties, time management issues,

Louisville Cardinals kicker Cooper Ranvier (36) reacts after missing a three-point field goal attempt that could have given the Cards the lead late in the fourth quarter as Clemson edged Louisville 20-19 at L&N Stadium Friday, Nov. 14, 2025. The Cards are now 7-3.

Self-inflicted mistakes cost Louisville against Clemson

Louisville head football coach Jeff Brohm had a lot to answer for following the 20-19 home loss to Clemson on Friday.   The Cardinals continuously

Nov 14, 2025; Louisville, Kentucky, USA; Louisville Cardinals head coach Jeff Brohm talks with an official during the first half against the Clemson Tigers at L&N Federal Credit Union Stadium. Mandatory Credit: Jamie Rhodes-Imagn Images

NCAA Football: Clemson at Louisville

VIDEO: Louisville's Jeff Brohm, Miller Moss, Keyjuan Brown react to Clemson loss

For the first time since returning to his alma mater, Louisville has lost back-to-back home games under Jeff Brohm, after falling 20-19 to Clemson on

Nov 14, 2025; Louisville, Kentucky, USA; Louisville Cardinals kicker Nick Keller (98) reacts after missing a field goal attempt during the second half against the Clemson Tigers at L&N Federal Credit Union Stadium. Clemson defeated Louisville 20-19. Mandatory Credit: Jamie Rhodes-Imagn Images

How it happened: No. 20 Louisville controlled own fortune in 20-19 loss to Clemson

Our Opposition in-depth series will be released two days before each game this season and will provide an in-depth review of the opponent, including

Cade Klubnik, Clemson

Opposition in-depth: Week 12, Clemson

Louisville looks to keep its season alive this Friday night. The Cards face off against Clemson, in what could’ve been a bigger game than it has

Isaac Brown

Keys to the game: No. 20 Louisville takes on Clemson

Louisville football is still in control of its own destiny, but it has work to do following the 29-26 overtime loss to California.  Head coach Jeff

Nov 8, 2025; Louisville, Kentucky, USA; Louisville Cardinals head coach Jeff Brohm talks with an official during the second half against the California Golden Bears at L&N Federal Credit Union Stadium. California defeated Louisville 29-26. Mandatory Credit: Jamie Rhodes-Imagn Images

VIDEO: Louisville's Jeff Brohm, Keyjuan Brown, others look ahead to Clemson

Louisville football was handed its second loss of the season on Saturday night, this time at the hands of California, 29-26 in overtime.   The two

Nov 8, 2025; Louisville, Kentucky, USA; California Golden Bears wide receiver Jacob de Jesus (21) runs the ball against Louisville Cardinals defensive lineman Wesley Bailey (23) in overtime at L&N Federal Credit Union Stadium. California defeated Louisville 29-26. Mandatory Credit: Jamie Rhodes-Imagn Images

How it happened: California outlasts No. 15 Louisville 29-26 in overtime

The newly appointed 15th-ranked Louisville will square off against California this Saturday night to keep its college football playoff hopes alive.

Jaron-Keawe Sagapolutele, Cal

Keys to the game: No. 15 Louisville takes on California

There has to be a third.   There are three of every position in college football. Each team has a third quarterback, a third kicker, a third left

Louisville RB Keyjuan Brown waited his turn, now he's off and running

It was another slow start for 16th-ranked Louisville football in Blacksburg, Virginia, but the Cardinals eventually pulled away from Virginia Tech,

Nov 1, 2025; Blacksburg, Virginia, USA; Louisville Cardinals running back Isaac Brown (1) runs the ball for a touchdown against the Virginia Tech Hokies during the first quarter at Lane Stadium. Mandatory Credit: Brian Bishop-Imagn Images

How it happened: No. 16 Louisville runs past Virginia Tech 28-16

The Cardinals were the talk of the town last week after beating the no. 2 ranked Miami Hurricanes on the road, but that was last week.   This week,

Jeff-Brohm-Louisville-Florida-Gators

Three takeaways: Louisville fights off a feisty Boston College for a 38-24 win

19th-ranked Louisville football eventually took down Boston College 38-24 on Saturday night, but it wasn't necessarily a perfect performance for the

Louisville coach Jeff Brohm at the Card March at the Louisville versus Boston College game Saturday afternoon at L&N Stadium. Oct. 25, 2025

VIDEO: Louisville's Jeff Brohm, Keyjuan Brown, TJ Quinn, others react to 38-24 win over Boston College

Well, that was weird.   In a game that spanned almost four hours, there was a little bit of everything in No. 19 Louisville's 38-28 win over Boston

Oct 25, 2025; Louisville, Kentucky, USA; Louisville Cardinals running back Keyjuan Brown (22) runs the ball for a touchdown against the Boston College Eagles during the second half at L&N Federal Credit Union Stadium. Mandatory Credit: Jamie Rhodes-Imagn Images