If you like to target shoot, you should think about getting a 1911 model .45 cal
Its a classic gun that is accurate and really fun to shoot. However, becasue its single action only, it may not be a good nightstand or car gun (some people don't like the hammer cocked back, which you need to do w/ this one or you have to rack the slide when needed). I have a Springfield Mil-Spec which i will be selling because i bought a Sig Nitron 1911 that is really nice (great deals from one seller on gunbroker.com where i got mine w/ extra mags for about $700). Don't skimp on a 1911; springfield, colt, sig, or kimber or better and buy new. If you like revolvers (and who doesn't?), i would think about Smith and Wesson used 19 (blued) or 66 (stainless steel) that shoot .38 really easy and .357 just fine. The 586 or 686 is the **** from Smith in those calibers. Smith has the best single action trigger on the planet and their double action is sweet too. That's why i sold my Ruger GP100 which was a tank but a clunky trigger imo. Be careful about buying any new Smith's because of the trigger lock problems (the Hillary hole) and some quality control problems recently. They are definitely a gun to buy used.
Stuff i've owned and opinions:
Bersa Thunder 380: lots of jams; maybe limp wristing; C-
Glock 17: easy to clean, easy to shoot, great gun: A+
Springfiled Mil Spec 1911: great gun but i hate the sights which are really hard to change w/ staked front sight: B
Smith & Wesson 36 Chief's special from the '70's: the gun you see on old Hawaii 50 and Perry Mason shows; perfect for its goals; sold it like an idiot; A+.
Smith 66: great .357 just be careful shooting hot loads of .357; A because its not built to handle new .357 loads w/ high pressure;
Smith centennial 642: A perfect car or ccw gun but not fun to range shoot; A-
Browning Hi Power from 1972: get the '67 or earlier ring hammer if you can; beautiful design by the world's greatest gun engineer; extremely accurate; another single action only; A+