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Louisville's costly mistakes led to a 20-19 loss to Clemson. The Cards drop to 7-3 after an embarrassing amount of penalties, time management issues,

Louisville Cardinals kicker Cooper Ranvier (36) reacts after missing a three-point field goal attempt that could have given the Cards the lead late in the fourth quarter as Clemson edged Louisville 20-19 at L&N Stadium Friday, Nov. 14, 2025. The Cards are now 7-3.

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Self-inflicted mistakes cost Louisville against Clemson

For the first time since returning to his alma mater, Louisville has lost back-to-back home games under Jeff Brohm, after falling 20-19 to Clemson on

Nov 14, 2025; Louisville, Kentucky, USA; Louisville Cardinals kicker Nick Keller (98) reacts after missing a field goal attempt during the second half against the Clemson Tigers at L&N Federal Credit Union Stadium. Clemson defeated Louisville 20-19. Mandatory Credit: Jamie Rhodes-Imagn Images

How it happened: No. 20 Louisville controlled own fortune in 20-19 loss to Clemson

Our Opposition in-depth series will be released two days before each game this season and will provide an in-depth review of the opponent, including

Cade Klubnik, Clemson

Opposition in-depth: Week 12, Clemson

Louisville looks to keep its season alive this Friday night. The Cards face off against Clemson, in what could’ve been a bigger game than it has

Isaac Brown

Keys to the game: No. 20 Louisville takes on Clemson

Despite the overtime loss to California, a game in which the Cardinals were double-digit favorites, Louisville still has a chance at the ACC

Nov 2, 2024; Clemson, South Carolina, USA; Clemson Tigers quarterback Cade Klubnik (2) runs against Louisville Cardinals linebacker Stanquan Clark (6) during the second quarter at Memorial Stadium. Mandatory Credit: Ken Ruinard-Imagn Images

At a glance: Louisville hoping to bounce back versus Clemson on Friday

Louisville football was handed its second loss of the season on Saturday night, this time at the hands of California, 29-26 in overtime.   The two

Nov 8, 2025; Louisville, Kentucky, USA; California Golden Bears wide receiver Jacob de Jesus (21) runs the ball against Louisville Cardinals defensive lineman Wesley Bailey (23) in overtime at L&N Federal Credit Union Stadium. California defeated Louisville 29-26. Mandatory Credit: Jamie Rhodes-Imagn Images

How it happened: California outlasts No. 15 Louisville 29-26 in overtime

Editor’s Note: This article includes the latest college football injury intel from On3’s Chris Low, Brett McMurphy and Pete Nakos. This story

college football week 11 injury updates

On3 Football

College Football Injury Report: Latest Week 11 updates on Ryan Williams, Whit Weeks & more

Louisville continues to evolve into the College Football Playoff discussion and hopes to continue a three-game winning streak this weekend against

Louisville LB Stanquan Clark injury

Player availability report: No. 15 Louisville, California

Justin Wilcox

Opposition in-depth: Week 11, versus California

After picking up its seventh win of the season at Virginia Tech, No. 14 Louisville is creeping into the ACC title game and College Football Playoff

Cal quarterback Jaron-Keawe Sagapolutele

At a glance: No. 14 Louisville taking it "game-by-game" against California

No. 14 Louisville, coming off a 28-16 road victory at Virginia Tech, will host California (5-4, 2-3 ACC) this Saturday at L&N Stadium.   Head

Nov 1, 2025; Blacksburg, Virginia, USA; Louisville Cardinals head coach Jeff Brohm looks on before the game against the Virginia Tech Hokies at Lane Stadium. Mandatory Credit: Brian Bishop-Imagn Images

VIDEO: No. 14 Louisville's Jeff Brohm, Mark Hagen, players preview California

Louisville Cardinals defensive lineman Mason Reiger (95) gets an arm around Virginia Tech Hokies quarterback Kyron Drones (1) as the Cards rolled past Virginia Tech 34-3 Saturday. Nov.4, 2023.

Opposition in-depth: Week 10, at Virginia Tech

No. 16 Louisville (6-1, 3-1 ACC) heads on the road for the third time in conference play this season at Virginia Tech (3-5, 2-2 ACC) this

Oct 24, 2025; Blacksburg, Virginia, USA; Virginia Tech Hokies quarterback Kyron Drones (1) throws a pass against the California Golden Bears during the second quarter at Lane Stadium. Mandatory Credit: Brian Bishop-Imagn Images

At a glance: No. 16 Louisville heads to Virginia Tech for first time in 34 years

Following No. 16 Louisville's 38-24 win over Boston College on Saturday, head coach Jeff Brohm, offensive line coach Richard Owens, as well as

Louisville Cardinals defensive lineman Wesley Bailey (23) had a stop on Bowling Green Falcons wide receiver Allen Middleton (1) in the first half against Bowling Green at L&N Federal Credit Union Stadium in Louisville, Kentucky Sept. 20, 2025.

VIDEO: No. 16 Louisville's Jeff Brohm, Wesley Bailey, others preview Virginia Tech

Louisville enters its seventh game of the season at an all-time high. Coming off their Friday night lights upset over No. 2 Miami, the Cards will now

Oct 25, 2024; Chestnut Hill, Massachusetts, USA; Louisville Cardinals running back Isaac Brown (25) dives for a touchdown against the Boston College Eagles during the first half at Alumni Stadium. Mandatory Credit: Eric Canha-Imagn Images

One big thing: Louisville must keep foot on the gas against Boston College

After an upset victory at No. 2 Miami, a now 19th-ranked Louisville (5-1) heads back home to take on a struggling Boston College (1-6) that hasn't

Sep 27, 2025; Pittsburgh, Pennsylvania, USA; Louisville Cardinals running back Duke Watson (26) runs the ball against the Pittsburgh Panthers during the second quarter at Acrisure Stadium. Mandatory Credit: Charles LeClaire-Imagn Images

Player availability report: Boston College, No. 19 Louisville

Oct 18, 2025; Chestnut Hill, Massachusetts, USA; Boston College Eagles quarterback Grayson James (3) stiff arms UConn Huskies linebacker Aaron Key (5) during the first half at Alumni Stadium. Mandatory Credit: Bob DeChiara-Imagn Images

Opposition in-depth: Week nine, Boston College

Boston College (1-6) and No. 19 Louisville (5-1) are two teams going in opposite directions.   The Cardinals are coming off one of the biggest

Dylan Lonergan

At a glance: No. 19 Louisville can't overlook Boston College

Louisville hits the road for the second time this season. This time, taking on No. 2 Miami in South Beach, and unfortunately for the Cardinals, it

Nov 30, 2024; Lexington, Kentucky, USA; Louisville Cardinals running back Duke Watson (26) carries the ball into the end zone for a touchdown during the third quarter against the Kentucky Wildcats at Kroger Field. Mandatory Credit: Jordan Prather-Imagn Images

Player availability report: Louisville, No. 2 Miami

Miami QB Carson Beck

Opposition in-depth: Week eight, No. 2 Miami

Louisville’s three-headed monster of a running back room rotation was supposed to carry the Cardinals' offense under transfer quarterback Miller

Louisville’s Isaac Brown runs the ball against Virginia at L&N Stadium Saturday. Ocr. 4, 2025

Louisville’s Isaac Brown runs the ball against Virginia at L&N Stadium Saturday. Ocr. 4, 2025 © Scott Utterback/Courier Journal / USA TODAY NETWORK via Imagn Images

Where in the world is Louisville's ground game?

After last week’s come-from-behind victory on the road against Pitt, the Louisville Cardinals had to face another tough test versus No. 24 Virginia.

Oct 4, 2025; Louisville, Kentucky, USA; Louisville Cardinals quarterback Miller Moss (7) scrambles under the pressure of Virginia Cavaliers linebacker Kam Robinson (5) during the second half at L&N Federal Credit Union Stadium. Virginia defeated Louisville 30-27. Mandatory Credit: Jamie Rhodes-Imagn Images

Three takeaways: Costly turnovers lead to Louisville's OT loss against Virginia

college football week 6 injury updates

College football injury updates entering Week 6: Florida's Dallas Wilson set to make debut & more

There was a lot to like and also a lot not to like in Louisville's 34-27 win at Pittsburgh.   The Cards got off to a poor start, falling behind 17-0

Sep 27, 2025; Pittsburgh, Pennsylvania, USA; Louisville Cardinals wide receiver Chris Bell (0) celebrates his touchdown with tight end Nate Kurisky (85) and offensive lineman Jordan Church (74) against the Pittsburgh Panthers during the second quarter at Acrisure Stadium. Mandatory Credit: Charles LeClaire-Imagn Images

Five takeaways: Louisville shows grit at Pittsburgh

When adversity hits, stick to what you know.   With so many injury questions for both Louisville and Pittsburgh ahead of tomorrow’s game, the

Sep 20, 2025; Louisville, Kentucky, USA; Louisville Cardinals wide receiver Caullin Lacy (5) runs the ball for a touchdown against the Bowling Green Falcons during the first half at L&N Federal Credit Union Stadium. Mandatory Credit: Jamie Rhodes-Imagn Images