As <a href="https://www.on3.com/college/colorado-buffaloes/">Colorado</a> looks to return to its winning ways after two weeks playing against some of the nation’s best, they head to Tempe for a Pac-12 Conference battle against <a href="https://www.on3.com/college/arizona-state-sun-devils/">Arizona State</a>.



According to <a href="https://sportsbook.fanduel.com/football/ncaa-football-games">FanDuel Sportsbook</a>, Colorado will open the game as a six-point betting favorite over Arizona State on the road.



The two programs have played six times since 2016 with both teams claiming three wins a piece over that span. Before that, the Sun Devils won the first seven matches in the series dating back to 2007.



Of course, the Sun Devils are without the services of true freshman quarterback <a href="https://www.on3.com/db/jaden-rashada-52678/">Jaden Rashada</a> for the matchup after losing him to injury for an extended period of time. Rashada passed for 403 yards, three touchdowns and an interception after starting the first two games of the season.



He’s expected back in the mix over the next couple weeks as he nurses what head coach Kenny Dillingham described as an injury that has bothered him since high school.



The quarterback issues only go deeper from there. <a href="https://www.on3.com/db/trenton-bourguet-115380/">Trenton Bourguet</a> was named starting QB after Rashada went down — but ended up injuring his foot after two drives of his first start and missed a couple weeks before making this weekend’s start vs. <a href="https://www.on3.com/college/california-golden-bears/">Cal</a>. Former <a href="https://www.on3.com/teams/notre-dame-fighting-irish/">Notre Dame</a> quarterback <a href="https://www.on3.com/db/drew-pyne-39150/">Drew Pyne</a> is the emergency quarterback for the Sun Devils, but he’s been dealing with a leg injury of his own recently.



Meanwhile, Colorado has one of the most acclaimed quarterbacks in the country this season, <a href="https://www.on3.com/db/shedeur-sanders-107068/">Shedeur Sanders</a>. He completed 30 passes against <a href="https://www.on3.com/teams/usc-trojans/">USC</a> for 371 passing yards, four touchdowns and ranked No. 2 in the country in passing yards (1,781).



After a magical 3-0 start to the season, Colorado’s schedule reached its toughest point with a two-game stretch against two top-10 ranked teams in <a href="https://www.on3.com/teams/oregon-ducks/">Oregon</a> and the Trojans. FanDuel’s odds indicate Colorado to return to its winning ways beginning this week, and likely against <a href="https://www.on3.com/college/stanford-cardinal/">Stanford</a> for Week 7. 



One of the bigger questions for the Buffaloes moving forward is the injury timeline for two-way star <a href="https://www.on3.com/db/travis-hunter-144752/">Travis Hunter</a>. After suffering a lacerated liver during Week 3 against <a href="https://www.on3.com/college/colorado-state-rams/">Colorado State</a>, his original diagnosis has him missing Saturday’s game against ASU and for him to return the following week against the Cardinal — but that could change and should be monitored throughout the week.



Kickoff between the Buffaloes and Sun Devils is scheduled for 6:30 p.m. ET inside Mountain America Stadium live on the Pac-12 Network. The over/under total is set at 64.5 points.

mel-kiper-evaluates-impact-of-colorado-loss-on-shedeur-sanders-future

On3 Football

Colorado vs. Arizona State: Early point spread released on Buffaloes, Sun Devils

team image

The Main Board

Football

Basketball

Women's Basketball

Softball

Baseball

Teams

Fan Sites

Forums

Shows

team-link

College Football News

College Football Player Rankings

College Football Rankings

College Football Playoff

College Basketball News

Women's Sports

College

NIL News

NIL Valuation

NIL Deals

NIL Deal Tracker

Sports Business

Transfer Portal News

NCAA Transfer Portal News

NCAA Transfer Portal

Transfer Portal Rankings

Transfer Portal Team Rankings

Transfer Portal

NCAA Transfer Portal Home

Football Recruiting

Basketball Recruiting

Database

Team Rankings

Player Rankings

Industry Comparison

Commitments

Recruiting Prediction Machine

Recruiting

High School News

Schools

High School Search

Rankings

High School Rankings

Scores

High School Scores

High School

NFL Draft

NFL Draft News

Draft By Stars

College Draft History

College Draft Totals

NBA Draft

NBA Draft News

Draft

NASCAR

Culture

Sports Betting

About

On3 App

Advertise

Press

Contact

Alabama

Arizona State

Arizona

Arkansas

Auburn

Baylor

Boston College

California

Removed

Clemson

Colorado

Duke

Florida

Florida State

Georgia

Georgia Tech

Illinois

Indiana

Iowa

Iowa State

Kansas

Kansas State

Kentucky

Lettermen Row

Lettermen Lounge

Louisville

Maryland

Miami

Michigan State

Michigan

Minnesota

Mississippi State

Missouri

NC State

Nebraska

North Carolina

Northwestern

Notre Dame

Ohio State

Oklahoma

Oklahoma State

Ole Miss

Oregon

Oregon State

Penn State

Pittsburgh

Purdue

Rutgers

South Carolina

Stanford

Syracuse

Tennessee

Texas A&M

Texas

Texas Tech

UCLA

Utah

Vanderbilt

Virginia

Virginia Tech

Wake Forest

Washington

Washington State

West Virginia

Wisconsin

BamaOnLine

BOL Round Table

Inside Texas

IT Members Only

DawgsHQ

Dawg Walk

Scoop Duck

Recruiting & Sports

AuburnSports

The Corner

WeAreSC

GarryP's Trojan Huddle

The Wolverine

The Fort

The Lions Den

The Wolfpacker

The Wolves’ Den

GatorsOnline

Swamp Talk

Alabama A&M

Alabama State

Albany

Alcorn State

Abilene Christian

Appalachian State

Akron

Army

Austin Peay

Arkansas-Pine Bluff

Arkansas-Little Rock

Arkansas State

Air Force

Ball State

American

Wofford

Winthrop

Wisconsin-Milwaukee

Wisconsin-Green Bay

Wichita State

Western Carolina

Volleyball

Gymnastics

Men's Lacrosse

Women's Lacrosse

Men's Soccer

Women's Soccer

Women's Track

Men's Golf

Women's Golf

Men's Hockey

Women's Hockey

Men's Swimming

Women's Swimming

Wrestling

Men's Tennis

Women's Tennis

Annual $1

Annual Premium

Annual $1 

Monthly

Annual

Unlimited Access to This and All Articles.

Article (On3 Plus Rivals)

Forum (On3 Plus Rivals)

Intro

Join

College scoop, experts, and community - all in one.

Colorado vs. Arizona State: Early point spread released on Buffaloes, Sun Devils

2026 All-America Team

5-Star Countdown

Duke, Darian Mensah

NCAA files motion

Charles Bediako