Against Creighton you can't do it. They play too fast, pass too well and space the floor with precision. Every player on their team is an outside threat except for Owen Freeman who is a classic paint Center but he's only averaging 12 minutes per game over the last 5 games.
6'8 235 lb Jasen Green is more of an inside-playing PF/C who has outside shooting ability, He's 9 for 23 (39.1%) from 3 so its definitely a part of his game that needs to be respected but he's probably the guy I'd put Payne/Hines on as he takes 70% of his shots in the paint or at the rim.
6'10" 235 lb Isaac Traudt is their other Big and leads the team in 3-pointers made (30 for 77, 39%). He is the poster-child for today's analytical game. He only shoots 3s and layups. 85% of his attempts are from 3 and the rest are at the rim. He's a better version of Ben Gold, gets a lot of pick and pops and dives to the rim. I'd put Fisher and Rivera on him.
If Freeman and Green were in the game together you could try Hines & Payne but I don't think it's a good idea.
We are a defense that strives on pressure and switching on the perimeter and throwing one of our Bigs out there without practicing it wouldn't be effective. I also think our offense would be out of synch, hurt our spacing and it could put our Bigs in potential foul trouble. Would obviously help our rebounding and our blocked shots but I don't think its something we should experiment with now.
Down the road if all 3 of our Bigs are healthy and playing well, you could experiment with it in practice but i think we just have to keep working with Fisher, Rivera and Dar to get more out of the 4 spot.