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Louisville’s season may feel over with just two games remaining in the regular season, and a chance at an ACC Championship Game or College Football

Oct 5, 2024; Louisville, Kentucky, USA; Southern Methodist Mustangs quarterback Kevin Jennings (7) runs the ball against the Louisville Cardinals during the first half at L&N Federal Credit Union Stadium. Southern Methodist defeated Louisville 34-27. Mandatory Credit: Jamie Rhodes-Imagn Images

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At a glance: Louisville in a "one-game season" at SMU

Our Opposition in-depth series will be released two days before each game this season and will provide an in-depth review of the opponent, including

Cade Klubnik, Clemson

Opposition in-depth: Week 12, Clemson

Ahead of Friday night's Louisville and Clemson game, the ACC has released its initial player availability report for both teams.  The Cardinals are

Nov 2, 2024; Clemson, South Carolina, USA; Louisville Cardinals running back Isaac Brown (25) runs the ball against Clemson Tigers cornerback Jeadyn Lukus (10) during the second quarter at Memorial Stadium. Mandatory Credit: Ken Ruinard-Imagn Images

Player availability report: No. 20 Louisville, Clemson

Louisville looks to keep its season alive this Friday night. The Cards face off against Clemson, in what could’ve been a bigger game than it has

Keys to the game: No. 20 Louisville takes on Clemson

Despite the overtime loss to California, a game in which the Cardinals were double-digit favorites, Louisville still has a chance at the ACC

Nov 2, 2024; Clemson, South Carolina, USA; Clemson Tigers quarterback Cade Klubnik (2) runs against Louisville Cardinals linebacker Stanquan Clark (6) during the second quarter at Memorial Stadium. Mandatory Credit: Ken Ruinard-Imagn Images

At a glance: Louisville hoping to bounce back versus Clemson on Friday

Editor’s Note: This article includes the latest college football injury intel from On3’s Chris Low, Brett McMurphy and Pete Nakos. This story

college football week 11 injury updates

On3 Football

College Football Injury Report: Latest Week 11 updates on Ryan Williams, Whit Weeks & more

Louisville continues to evolve into the College Football Playoff discussion and hopes to continue a three-game winning streak this weekend against

Louisville LB Stanquan Clark injury

Player availability report: No. 15 Louisville, California

Justin Wilcox

Opposition in-depth: Week 11, versus California

After picking up its seventh win of the season at Virginia Tech, No. 14 Louisville is creeping into the ACC title game and College Football Playoff

Cal quarterback Jaron-Keawe Sagapolutele

At a glance: No. 14 Louisville taking it "game-by-game" against California

No. 14 Louisville, coming off a 28-16 road victory at Virginia Tech, will host California (5-4, 2-3 ACC) this Saturday at L&N Stadium.   Head

Nov 1, 2025; Blacksburg, Virginia, USA; Louisville Cardinals head coach Jeff Brohm looks on before the game against the Virginia Tech Hokies at Lane Stadium. Mandatory Credit: Brian Bishop-Imagn Images

VIDEO: No. 14 Louisville's Jeff Brohm, Mark Hagen, players preview California

In the fourth quarter of Louisville's 28-16 win over Virginia Tech on Saturday, Cardinals running back Isaac Brown left the game after suffering an

Greg McElroy is extremely high on Louisville running back Isaac Brown entering the 2025 season.

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Louisville

Isaac Brown injury update: Jeff Brohm shares latest on Louisville RB

This one had “trap game” written all over it for Louisville.   Jeff Brohm and his squad knew that the performance in the first half of this game

Nov 1, 2025; Blacksburg, Virginia, USA; Louisville Cardinals defensive back Antonio Watts (9) tackles Virginia Tech Hokies running back Marcellous Hawkins (27) during the first quarter at Lane Stadium. Mandatory Credit: Brian Bishop-Imagn Images

Three takeaways: No. 16 Louisville rallies behind near perfect defense at Virginia Tech

It was another slow start for 16th-ranked Louisville football in Blacksburg, Virginia, but the Cardinals eventually pulled away from Virginia Tech,

Nov 1, 2025; Blacksburg, Virginia, USA; Louisville Cardinals running back Isaac Brown (1) runs the ball for a touchdown against the Virginia Tech Hokies during the first quarter at Lane Stadium. Mandatory Credit: Brian Bishop-Imagn Images

How it happened: No. 16 Louisville runs past Virginia Tech 28-16

A chill has overtaken college football fans. Not from the increasingly approaching winter weather, but from the fact two months of action has already

Rutgers Football WR KJ Duff

On3 Impact Ratings: The Top Risers from Week9

The Cardinals were the talk of the town last week after beating the no. 2 ranked Miami Hurricanes on the road, but that was last week.   This week,

Jeff-Brohm-Louisville-Florida-Gators

Three takeaways: Louisville fights off a feisty Boston College for a 38-24 win

Well, that was weird.   In a game that spanned almost four hours, there was a little bit of everything in No. 19 Louisville's 38-28 win over Boston

Oct 25, 2025; Louisville, Kentucky, USA; Louisville Cardinals running back Keyjuan Brown (22) runs the ball for a touchdown against the Boston College Eagles during the second half at L&N Federal Credit Union Stadium. Mandatory Credit: Jamie Rhodes-Imagn Images

How it happened: No. 19 Louisville stumbles past Boston College

Louisville enters its seventh game of the season at an all-time high. Coming off their Friday night lights upset over No. 2 Miami, the Cards will now

Oct 25, 2024; Chestnut Hill, Massachusetts, USA; Louisville Cardinals running back Isaac Brown (25) dives for a touchdown against the Boston College Eagles during the first half at Alumni Stadium. Mandatory Credit: Eric Canha-Imagn Images

One big thing: Louisville must keep foot on the gas against Boston College

University of Louisville football got off to a sizzling start offensively in the wire-to-wire 24-21 upset victory at No. 2 Miami on Friday.   It was

Oct 17, 2025; Miami Gardens, Florida, USA; Louisville Cardinals quarterback Miller Moss (7) celebrates after winning the game against the Miami Hurricanes at Hard Rock Stadium. Mandatory Credit: Sam Navarro-Imagn Images

How it happened: Louisville stuns No. 2 Miami

Louisville’s three-headed monster of a running back room rotation was supposed to carry the Cardinals' offense under transfer quarterback Miller

Louisville’s Isaac Brown runs the ball against Virginia at L&N Stadium Saturday. Ocr. 4, 2025

Louisville’s Isaac Brown runs the ball against Virginia at L&N Stadium Saturday. Ocr. 4, 2025 © Scott Utterback/Courier Journal / USA TODAY NETWORK via Imagn Images

Where in the world is Louisville's ground game?

After last week’s come-from-behind victory on the road against Pitt, the Louisville Cardinals had to face another tough test versus No. 24 Virginia.

Oct 4, 2025; Louisville, Kentucky, USA; Louisville Cardinals quarterback Miller Moss (7) scrambles under the pressure of Virginia Cavaliers linebacker Kam Robinson (5) during the second half at L&N Federal Credit Union Stadium. Virginia defeated Louisville 30-27. Mandatory Credit: Jamie Rhodes-Imagn Images

Three takeaways: Costly turnovers lead to Louisville's OT loss against Virginia

college football week 6 injury updates

College football injury updates entering Week 6: Florida's Dallas Wilson set to make debut & more

college football week 5 injury updates

College football injury updates entering Week 5: Georgia missing starting OL & more

When adversity hits, stick to what you know.   With so many injury questions for both Louisville and Pittsburgh ahead of tomorrow’s game, the

Sep 20, 2025; Louisville, Kentucky, USA; Louisville Cardinals wide receiver Caullin Lacy (5) runs the ball for a touchdown against the Bowling Green Falcons during the first half at L&N Federal Credit Union Stadium. Mandatory Credit: Jamie Rhodes-Imagn Images

One big thing: Louisville's quick game can give Pittsburgh fits

For the first time, the ACC will release player availability reports two days before conference football, basketball, and baseball games.   Reporting

Nov 23, 2024; Louisville, Kentucky, USA; Louisville Cardinals running back Isaac Brown (25) runs against the Pittsburgh Panthers during the second half at L&N Federal Credit Union Stadium. Louisville defeated Pittsburgh 37-9. Mandatory Credit: Jamie Rhodes-Imagn Images

Player availability report: Louisville, Pittsburgh

The Atlantic Coast Conference and its television partners have announced the football game times and networks for Week 6 of the season, which

Oct 12, 2024; Charlottesville, Virginia, USA; Louisville Cardinals running back Isaac Brown (25) carries the ball past Virginia Cavaliers safety Corey Thomas Jr. (3) to score a touchdown during the second half at Scott Stadium. Mandatory Credit: Amber Searls-Imagn Images